25 August 2015
New article in Scientific Reports
Together with their collaboration partners at the University in Antwerp, Belgium, PhD student Jens-Peter David and associate professor Nicole Schmitt have published an article in Scientific Reports.
They addressed mechanisms underlying the diverse function of the potassium channel Kv2.1. The activity of this channel is crucial for neuronal excitability and neuroprotection. One of Kv2.1's ways to accommodate a variety of functions in different neurons is to interact with other proteins. In this study, we found a new player in the game - a protein termed KCNE5. Using a variety of techniques, we found a novel protein complex consisting of Kv2.1/Kv6.4/KCNE5 that in vivo might contribute to tissue-specific fine-tuning of excitability.
Scientific Reports is an online, open access journal from the publishers of Nature and ranks 5th among all multidisciplinary science primary research journals